Since recent reviews have highlighted the pivotal role of podocytes in the progression of Diabetic Nephropathy (Carney, 2017; Dai et al., 2017), we asked whether we could employ podometric methodology using transducin-like enhancer of split 4 (TLE4) as a nuclear podocyte-specific marker, and glomerular epithelial protein-1 (GLEPP1), a glomerular marker to quantify podocyte density in Diabetic Nephropathy tissue, and further assess the same cohort for expression and localization of YAP. This evidence concerns the gene TLE4 and diabetic kidney disease.