In the remaining circulatory DCs in sepsis patients, HLA-DR, CD80, and CD86 are downregulated, while IL-10 production is increased (Faivre et al., 2012), which is consistent with their reduced ability to induce effector T cell responses and their ability to prevent the response of T cells and the proliferation of Treg cells (Faivre et al., 2007; Wen et al., 2008). Here, IL10 is linked to Sepsis.