Emerging evidence has confirmed that the mechanisms of TCM treatment for AD include improving Aβ plaques, abnormal phosphorylation of tau protein, neuroinflammation, and oxidative stress (Tobore, 2019), as well as the improvement of microglia activity (Xia et al., 2017), regulation of heat shock protein pathway, MAPK pathway, mitochondrial membrane potential and release of cytochrome C, and so on (Zong et al., 2016; Dinda et al., 2019). This evidence concerns the gene MAPT and Alzheimer disease.