Scott Brakenridge et al. found that increased GLP-1 levels within 24 h of sepsis are closely associated with early death, and in survivors, a sustained increase in GLP-1 levels after 14 days was also associated with severe dysfunction after 6 months, and the changes were associated with IL-6 secretion (Brakenridge et al., 2019). Here, GCG is linked to Sepsis.