Although other potential signaling molecules within the GluN2B/NO pathway remain to be uncovered, one of the major pathways downstream of NMDA/nNOS is a carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON)/dexamethasone-induced ras protein 1 (Dexras1), which is an alternative promising therapeutic target for treating mood disorders, such as anxiety (Zhu et al., 2014; Zhu et al., 2020). This evidence concerns the gene GRIN2B and mood disorder.