For instance, according to the results of network pharmacology, although we believed that the effect of XTN on CHD is closely related to cell apoptosis, only the potential effects of XTN on classical apoptotic factors Caspase-3 and Bax/Bcl-2 were explored, whereas the possibility of upstream regulatory pathways such as PI3K-Akt pathway were not considered in the current study. Here, AKT1 is linked to coronary artery disorder.