Furthermore, silencing of alanine aminotransferase in hepatocytes in mice with obesity and diabetes abrogated hyperglycaemia and restored skeletal muscle protein synthesis improving insulin sensitivity, which suggests that liver aminotransferase has a key role in inducing skeletal muscle atrophy in T2D (Okun et al., 2021). Here, GPT is linked to obesity due to melanocortin 4 receptor deficiency.