AKT1 and liver cancer: For the PI3K/AKT/mTOR pathway, significantly elevated expression of the PI3K (p = 1.62E-12) (Supplementary Figure 1E), AKT (p = 0.0049) (Supplementary Figure 1F) and mTOR (p = 1E-12) (Supplementary Figure 1G) were observed in liver cancer patient tissues as compared to normal liver tissues.