The current research on IBD is focused on helper T cells (Th) as previous studies have confirmed that CD is an inflammation condition dominated by Th-1, which produce a large amount of IFN-g and TNF after induction by IL-12, and UC is associated with the Th-2 cells, in which there is a higher production of IL-4, IL-5, and IL-13 while the level of IFN-g is normal (Alfen et al., 2018; Barnig et al., 2019; Bauché et al., 2020; Tindemans et al., 2020). Here, IFNG is linked to inflammatory bowel disease.