TNF and Sepsis: In the presence of a cytokine storm causing DIC, sepsis, Jinye Baidu Granules particles exert a protective effect on liver microsomal activity, calcium homeostasis, in addition to resisting free radical production and activity, and reducing levels of circulating or tissue inflammatory cytokines (such as TNF-α, IL1, IL6, and IL8) and inhibiting dysregulated TNF-α release, which lead to the reduction of vascular endothelial cells and organ damage and prevention of the activation of the blood coagulation system (Shi et al., 2020a).