SLC4A1 and histiocytic sarcoma: Mariani et al. reported that band three deficiencies were the most common protein abnormalities (54%) in European HS patients (Mariani et al., 2008); however, only 18 mutations (11%) dispersed throughout the whole gene have been reported in Chinese HS patients (Supplementary Table 1 and Figure 3), and most of these SLC4A1 mutations were missense mutations, this result is consistent with some previous reports (Yawata et al., 2000; Barneaud-Rocca et al., 2011; Reithmeier et al., 2016).