We then summarized and analyzed the mutational characteristics of ANK1 mutations in Chinese HS patients and found that exon 8, 9, 26, and 28 of ANK1 gene are high frequency mutant exons (Figure 2) and types of ANK1 mutations in Chinese HS patients include nonsense mutations (36%), frameshift mutations (27%, containing small or gross deletions, insertions), missense mutations (18%), splicing abnormalities (15%) and start codon mutations (4%), but no regulatory mutations and complex rearrangements. The gene discussed is ANK1; the disease is histiocytic sarcoma.