We plotted the regulatory networks of these transcription factors against screened cancer driver genes, of which AR, CPEB3, ESR1, PTPRB, and CBFA2T3 are lower expressed in cancer tissues compared with the paracancerous tissues (p < 0.05), and the others are higher expressed in cancer tissues (p < 0.05) (Figure 2B). Here, ESR1 is linked to cancer.