TNF and Mental deterioration: These key proteins included the anti-inflammatory cytokines IL4 and IL10 and the pro-inflammatory cytokines TNF-alpha and IL6 that balance appears to be important for maintaining a less pathologic immune profile, as suggested by a recent study of Taipa and coworkers that found that a collection of both pro-inflammatory and anti-inflammatory cytokines were correlated with less cognitive decline in patients after one year (Taipa et al., 2019).