Molecular function annotations also defined NADPH oxidation, fatty acid and arachidonic acid binding as well as glutamate signaling as significant functions, therefore connecting neuroinflammation to NADPH oxidases and arachidonic acid metabolism critically involved in the neuropathogenesis of Alzheimer's disease (Fricker et al., 2018; Tarafdar and Pula, 2018; Chen et al., 2020). This evidence concerns the gene FMO5 and early-onset autosomal dominant Alzheimer disease.