Here again, both beneficial and detrimental roles were attributed to TLRs and for instance TLR7, TLR8 and TLR9 signaling could enhance microglial amyloid beta uptake in the early stage of Alzheimer’s disease, but over time contribute to sustained neuroinflammation (Gambuzza et al., 2014). The gene discussed is TLR7; the disease is Alzheimer disease.