Here again, both beneficial and detrimental roles were attributed to TLRs and for instance TLR7, TLR8 and TLR9 signaling could enhance microglial amyloid beta uptake in the early stage of Alzheimer’s disease, but over time contribute to sustained neuroinflammation (Gambuzza et al., 2014). Here, TLR8 is linked to early-onset autosomal dominant Alzheimer disease.