CRP and early-onset autosomal dominant Alzheimer disease: Finally, our study identified CRP that is increased in brain tissue from Alzheimer’s disease patients (Wood et al., 1993; Iwamoto et al., 1994) and that should be considered not only as a marker but also as a driver of neuroinflammation, since CRP can bind to the complement factor 1q (C1q) and activate the classical complement cascade (Slevin et al., 2015; Braig et al., 2017).