Genetic studies including genome-wide studies have also associated inflammation-related genes to the etiology of Alzheimer’s disease (i.e. ABCA7, CLU, CR1, HLA-DRB1, HLA-DRB5, PICALM, and TREM2) (Lambert et al., 2009; Jun et al., 2010; Guerreiro et al., 2013; Lambert et al., 2013; Jansen et al., 2019), further supporting the concept of neuroinflammation as a pathogenic factor in Alzheimer’s disease. Here, HLA-DRB5 is linked to early-onset autosomal dominant Alzheimer disease.