Drug-protein interaction analysis also pictured small molecules such as thalidomide that reduces the production of TNF-alpha (Sampaio et al., 1991; Gabbita et al., 2012) and that more potent derivative 3,6-dithiothalidomide ameliorated cognition in a rat models of LPS-induced sustained microglia activation (Belarbi et al., 2012) and in a triple transgenic mouse model of Alzheimer's disease (Tweedie et al., 2012). Here, TNF is linked to Alzheimer disease.