Most overrepresented molecular function annotations were amyloid beta binding activity—an activity presented by proteins such as ITGAM (also named CD11b) (Goodwin et al., 1997) and TLR4 (Liu et al., 2020)—as well as cytokine receptor binding activity, further linking the amyloid peptide to the innate immune response in Alzheimer's disease. Here, TLR4 is linked to early-onset autosomal dominant Alzheimer disease.