For example, resveratrol protects the brain from NLRP3 injury by inhibiting the activation of NLRP3 inflammatory bodies through Sirt1-dependent autophagy; ginkgetin can alleviate cerebral ischemia/reperfusion induced autophagy and apoptosis by inhibiting the NF-κB/p53 signaling pathway (He et al., 2017; Yu et al., 2018; Pan et al., 2019). This evidence concerns the gene TP53 and brain ischemia.