Mitochondrial autophagy can play a neuroprotective role by inhibiting apoptosis in the model of transient ischemia and hypoxia, in which the expression of Beclin-1 protein and the ratio of LC3-II/I is increased, while the expression of p62, TOM20, and HSP60 is decreased, and the progression of cerebral infarction is mild (Huang et al., 2016). This evidence concerns the gene TOMM20 and cerebral infarction.