Chronic stress in the AD brain promotes the proliferation of glial cells and increases secretion of stress-induced cytokines, such as interleukin (IL)-1β, IL-6, IL-12, IL-18, and tumor necrosis factor-alpha (TNF-α), resulting in impaired neurogenesis and synaptic plasticity (Ricci et al., 2012). The gene discussed is TNF; the disease is Alzheimer disease.