RNF213 and Moyamoya disease: RING finger protein 213 (RNF213) is a susceptibility gene for large artery atherosclerosis (LAA) (Okazaki et al., 2019) as well as moyamoya disease (MMD), which is a progressive steno-occlusive disease of the circle of Willis (Kamada et al., 2011; Liu et al., 2011).