In addition, the NPI total score and executive function score were only found correlated with tau SUVR or volume of the hippocampal subfields with the presence of elevated amyloid pathology, which indicates that the decline of behavior and executive function is consistent with the neurodegenerative alterations of the HF when the subject was in the Alzheimer’s pathologic process. The gene discussed is MAPT; the disease is amyloidosis.