In recent years, several studies have shown that IDH mutation could repress the infiltration of immune cells and mediate immune evasion in gliomas (Amankulor et al., 2017; Berghoff et al., 2017; Kohanbash et al., 2017; Bunse et al., 2018; Richardson et al., 2019). Here, IDH2 is linked to central nervous system cancer.