In another common AD mouse model that expresses five familial AD mutations (5xFAD), it was demonstrated that the anti-inflammatory Bifidobacterium longum, which is able to suppress human gut microbiota LPS production and LPS-induced NF-κB activation in LPS-stimulated microglial BV-2 cells, from healthy human fecal microbiota could alleviate cognitive decline in 5xFAD transgenic and aged mice (Lee et al., 2019). This evidence concerns the gene NFKB1 and Alzheimer disease.