To better understand whether LV-mGluR7 treatment was sufficient to alleviate anxiety-like behaviors in mouse models of ASD, as shown in Figures 4A,B, we next conducted open field tests in which the overexpression of mGluR7 in VPA-treated mice was associated with increased time spent in the center of the open field relative to LV-GFP treatment (F(2,27) = 38.23, p < 0.001), similar to behaviors observed in C57B6L/J mice (p > 0.05). This evidence concerns the gene GRM7 and Anxiety.