Indeed, an increased density of cortical A2AR has been reported in animal models of epilepsy (Rebola et al., 2005; Cognato et al., 2010; Canas et al., 2018; Crespo et al., 2018), Rasmussen’s encephalopathy (He et al., 2020), TBI (Zhao et al., 2017), AD (Espinosa et al., 2013; Viana da Silva et al., 2016; Silva et al., 2018), Lyme neuroborreliosis (Smith et al., 2014), ALS (Seven et al., 2020), or chronic stress/depression (Kaster et al., 2015; Machado et al., 2017), as well as in the diseased human brain (Albasanz et al., 2008; Temido-Ferreira et al., 2020). The gene discussed is ADORA2A; the disease is amyotrophic lateral sclerosis.