ADORA2A and brain disorder: Notably, A2AR overfunction seems to be an early event in different brain disorders (reviewed in Cunha, 2016), although A2AR antagonists seem to maintain their neuroprotective profile after the establishment of symptoms (e.g., Kaster et al., 2015; Faivre et al., 2018; Orr et al., 2018; Silva et al., 2018).