NGF and Brain atrophy: Moreover, the patients’ responses to the NGF-treatment indicated that approximately half of the patients responded to the ECB-NGF-treatment with increased cholinergic markers (e.g., ChAT activity) in the CSF, correlating to improved cognition and brain glucose metabolism (Karami et al., 2015), less brain atrophy (Ferreira et al., 2015), and normalization of the EEG-pattern (unpublished data).