A total of 46 genes showed an obvious relationship with the OS of osteosarcoma using a p value of less than 0.05 as the selection criteria (Figure 2A), of which MYC (HR = 1.5, 95% CI: 1.1−2.2, p = 0.024) and BNIP3 (HR = 1.5, 95% CI: 1.1−2, p = 0.0073) were risk genes. Here, BNIP3 is linked to osteosarcoma.