Furthermore, WIPI1 was a relevant novel melanoma marker [81], and the increased expression of WIPI1 indicated poor clinical outcome in uveal melanoma [82] In osteosarcoma, WIPI1 expression was obviously elevated, which promoted the proliferation of osteosarcoma cells through regulating CDKN1A expression [83]. The gene discussed is CDKN1A; the disease is osteosarcoma.