In this regard, previous research showed that the increased levels of IL-23 and IL-17 are linked to the pathogenesis of many autoimmune diseases, such as pediatric systemic lupus erythematosus [20], systemic lupus erythematosus, multiple sclerosis ankylosing spondylitis, Graves' disease, Crohn's disease [21] psoriasis, psoriasis arthritis [22, 23], chronic spontaneous urticarial [24], morphea [25], bullous pemphigoid [26], pemphigus vulgaris [27, 28], pemphigus foliaceus [29], and vitiligo [30]. This evidence concerns the gene IL37 and localized scleroderma.