TNF and hematocrit: INF-γ not only enhances remodeling of the extracellular space of salivary glands through upregulation the production of metalloproteinases [39] but, similar to TNF-α and IL-12, activates intrinsic apoptosis pathways [37, 38, 40], and IL-6 and IL-1 boost apoptotic damage by exposing cytosolic autoantigen present in HT [41].