FGF23 and chronic kidney disease: Excess FGF23 during CKD progression is associated with cardiovascular mortality via direct and reversible effects of FGF23 on cardiac myocytes that lead to the development of LVH.4,5,59–61 In the present study, inhibition of FGF23 production by genetic deletion of Lcn2 may have prevented the development of LVH and increased survival in Col4a3KO mice with CKD.