In CKD, elevated FGF23 is associated with the development of LVH, heart failure, and death, and administration of FGF23 to WT mice induces LVH.4 As previously reported,1,34 C57Bl6-Col4a3KO mice show a shortened lifespan and die at an average of 23 weeks of age (Fig. 4a). The gene discussed is FGF23; the disease is chronic kidney disease.