Among these, multiple studies showed contributions of inflammation,8 iron deficiency,9 anemia,2 and local osteocyte defects.1 Notably, circulating FGF23 levels increase as kidney disease progresses, suggesting that kidney-bone crosstalk may contribute to excessive production of FGF23 by bone in response to kidney injury.10,11. Here, FGF23 is linked to Iron deficiency anemia.