LCN2 and chronic kidney disease: Development of LVH in C57Bl6-Col4a3KO mice with advanced CKD may contribute to a shortened lifespan, as an increase in whole heart and left ventricular mass in Col4a3KO mice eventually leads to impaired cardiac function (Fig. 4b–f), and rescue of LVH is associated with extended lifespan in this model.1 Despite a similar degree of CKD and anemia, Lcn2 deletion improved survival, as CPD mice lived on average 3 weeks longer than Col4a3KO mice (Fig. 4a).