LCN2 and chronic kidney disease: We reported that C57Bl6–Col4a3KO mice experience progressive declines in renal function and develop LVH.1,34 Here, we report that circulating levels of LCN2 increased in an age-dependent manner in WT and Col4a3KO mice, and were higher in Col4a3KO mice with CKD than in WT mice (Fig. 2a).