There was no statistically significant difference between any clinico-pathological variable and total TIL density (CD3+ or CD8+), although high CD8+ cell density tended to be associated with poor differentiation of squamous cell carcinoma (P = 0.0822) and vascular invasion (P = 0.0581), as shown in Table 3. The gene discussed is CD8A; the disease is squamous cell carcinoma.