Third, tumor immunological factors, including PD-L1/2 expression, were not evaluated.6,19,57 In fact, Teng et al reported that so-called “hot tumors” with both high expression of PD-L1 and high TIL numbers in malignant melanoma are the most responsive tumors to ICI.58–61 Accordingly, it is important to establish a new evaluation criterion that combines TIL density and other immune-related factors to further improve prognostic accuracy. This evidence concerns the gene CD274 and neoplasm.