Co-expression analysis of NOP2 and immune checkpoint molecules or immune cell pathways presented that this gene was significantly related to CD274 (PDL1), PDCD1 (PD1), CTLA4, LAG3, Actived CD4 T cells pathway, activated dendritic cell pathway, immature dendritic cell pathway, mast cell pathway, and monocyte pathway in ccRCC from TCGA dataset. The gene discussed is CD4; the disease is nonpapillary renal cell carcinoma.