NOP2 and nonpapillary renal cell carcinoma: In summary, our outcomes shed light on that NOP2 could serve as a potential prognostic predictor of OS for ccRCC and five NOP2-related signaling pathways were identified, containing cytokine-cytokine receptor interaction pathway, cytosolic DNA sensing pathway, glycerophospholipid metabolism pathway, primary immunodeficiency pathway, and intestinal immune network for IgA production pathway.