As displayed in Figure 6 and Table 3, five eligible signaling pathways exhibiting significant enrichment in the high-NOP2 expression phenotype were finally identified, containing cytokine-cytokine receptor interaction pathway, Cytosolic DNA sensing pathway, Glycerophospholipid metabolism pathway, Primary immunodeficiency pathway and Intestinal immune network for IgA production pathway. Here, CD79A is linked to inborn error of immunity.