Co-expression analysis of NOP2 and immune checkpoint molecules or immune cell pathways presented that this gene was significantly related to CD274 (PDL1), PDCD1 (PD1), CTLA4, LAG3, Actived CD4 T cells pathway, activated dendritic cell pathway, immature dendritic cell pathway, mast cell pathway, and monocyte pathway in ccRCC from TCGA dataset. This evidence concerns the gene NOP2 and nonpapillary renal cell carcinoma.