APOE and obesity due to melanocortin 4 receptor deficiency: Using this algorithm, all hug targets of metformin against obesity-related hypertension were identified accordingly, including IL6, CCL2, Leptin (LEP), Apolipoprotein B (APOB), serine protease inhibitor clade E member 1 (SERPINE1), Apolipoprotein E (APOE) (Figure 4).