VEGFA and cancer: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen and angiogenic factor that binds to endothelial cells via tyrosine kinase receptors (two subtypes: VEGFR – 1 / KDR and VEGFR – 2 / Flt) in the pulmonary circulation, which could be related to cancer - like cellular responses.