CRP and ankylosing spondylitis: In the study with 147 ankylosing spondylitis (AS) patients, serum HMGB- 1 level of AS patients was significantly higher than in HC and it was correlated positively with AS disease activity indices such as Bath Ankylosing Spondylitis Disease activity index (BASDAI), Bath Ankylosing spondylitis Functional index (BASFI), Ankylosing spondylitis disease activity score-ESR (ASDAS-ESR), ASDAS-CRP, ESR, and CRP [31].