The combination of 5 or 10 μM GANT-61 with 100 or 200 nM ZEN-3365 led to a significantly reduced growth of the AML cell lines MV4-11, HL60, KG-1, MOLM13, Kasumi-1, and OCI-AML3 in comparison to GANT-61 treatment alone (Fig. 3a–f). Here, RUNX2 is linked to acute myeloid leukemia.