More importantly, stable expressing a hnRNPLΔRRM3 mutant that cannot be recognized and degraded by FBXO16 phenocopied FBXO16 deficiency in ovarian cancer cells, indicating FBXO16 promotes the proliferation and invasion of ovarian cancer cells mainly via hnRNPL degradation. The gene discussed is FBXO16; the disease is ovarian carcinoma.