The challenge with OVA plus LPS and either urban PM2.5 or ASD exacerbated OVA-induced lung eosinophilia along with T-helper 2 cytokine and eosinophil-relevant chemokine production in BALF as well as the production of OVA-specific IgE in serum. The gene discussed is IGHE; the disease is Increased total eosinophil count.