In vitro studies confirm potential involvement of ASD in exacerbating the inflammatory process of bronchial tissue and asthmatic symptoms through the production of inflammatory mediators and tissue eosinophilia via TLR/MyD88 signaling pathways (Ichinose et al., 2008a, He et al., 2013a, He et al., 2016a). The gene discussed is MYD88; the disease is Increased total eosinophil count.