L3MBTL2 and acute lymphoblastic leukemia: We infected with shRNAs (short hairpin RNA) the previously described mouse Beko T-ALL (T-cell acute lymphoblastic leukemia) cell line, where L3MBTL2 interacts with RBPJ at endogenous level (Additional file 2: Fig. S1f) and that is constitutively active for Notch signal transduction and Notch target gene expression [8, 9, 35].