GZMB and neoplasm: Moreover, it also has been reported that cytotoxic lymphocytes, including CD8+ T cells and NK cells, contribute to the efficacy of certain chemotherapeutic drugs [4], such as cisplatinum, paclitaxel and doxorubicin, which have been shown to enhance the NK and CD8+ T cell-mediated killing as they increase the permeability of tumor cells towards the apoptosis inducing serine protease granzyme B [35].