Moreover, the activation of AKT and NF-κB signaling pathways could be regulated by the miR-146b-5p, which is linked with glioma cell proliferation and apoptosis, and survival of patients with glioma [37], but little is known about the epigenetic regulation of ITGA2 and the ATK/NF-kB/STAT3 axis in bladder cancer cells. This evidence concerns the gene AKT1 and urinary bladder cancer.