For more understanding of the molecular mechanisms downstream of lnc-STYK1-2 and miR-146b-5p, we analyzed the influence of lnc-STYK1-2 and its suppression of miR-146b-5p on the expression of ITGA2 and AKT/NFκB/STAT3 axis activation in bladder cancer cells. This evidence concerns the gene STYK1 and urinary bladder cancer.