Furthermore, AEBP1 is also considered to be involved in multiple disease and pathological processes, and increased levels of AEBP1 accompanying several signal pathway dysfunctions (such as NF-κB [37], Hedgehog [38], etc.)could be found in liver fibrosis [39], Alzheimer’s disease [40], breast epithelial cell hyperproliferation [38], abdominal aortic aneurysm [37] and colorectal cancers [41]. The gene discussed is AEBP1; the disease is early-onset autosomal dominant Alzheimer disease.