We further evaluated the expression levels of AEBP1 using exosome RNA from DKD and control subjects, and significant AEBP1 expression was found in DKD patients compared to T2DM patients (p = 0.023, Fig. 5D) or control subjects (p = 0.0009, Fig. 5D). The gene discussed is AEBP1; the disease is type 2 diabetes mellitus.