We analysed 28 widely reported m6A RNA methylation modulators in pancreatic cancer according to the TCGA and GTEx database, a higher expression of these modulators except METTL3 was found in patients with PAAD compared to the normal tissues, suggesting an alterant level of m6A RNA methylation may play a carcinogenic role in pancreatic cancer. Here, METTL3 is linked to familial pancreatic carcinoma.