METTL3 and pancreatic adenocarcinoma: We analyzed the relationship between the expression of the six modulators and the clinical characteristic of PAAD, and found a high expression of EIF3H, IG2BP3, IG2BP2, and LRPPRC was related to the maximum tumor dimension, while reduced expression of METTL3 may be associated with the maximum tumor dimension, overexpression of IGF2BP2 and LRPPRC was relevant to a higher histologic grade (Table 3).