The network results displayed 12 modulators function as risk factors in PAAD patients, including LRPPRC, IGF2BP2, IGF2BP3, HNRNPC, FMR1, EIF3H, EIF3A, FTO, CBLL1, RBM15, YTHDF3, and KIAA1429. This evidence concerns the gene YTHDF3 and pancreatic adenocarcinoma.