The results from GSEA showed that overexpression of IGF2BP2 and IGF2BP3 was related to the progression of cancer, IGF2BP3 may involve rearrangement of peripheral actin, which led to the formation of additional membrane protrusions, promoting cell invasiveness and tumor metastasis of pancreatic cancer [40], IGF2BP2 was confirmed to be an oncogenic factor; miR-141 was a downstream regulatory gene in the progression of pancreatic cancer in a previous study [41]. This evidence concerns the gene IGF2BP3 and familial pancreatic carcinoma.