CD8A and neoplasm: Dali et al. found a risen level of CD8+ cytotoxic T cells and natural killer (NK) cells while a reduced infiltration of myeloid-derived suppressor cells (MDSC) from Ythdf1−/− tumor mice compared to WT mice, besides, the therapeutic efficacy of PD-L1 checkpoint blockade is enhanced in Ythdf1−/− mice [35].