The phosphatidylinositol 3-kinase (PI3K)/Akt (PI3K/Akt) signaling pathway is a classical signaling pathway in cells, and has always been a focus of interest in various diseases including cancers [15], diabetes [16], PAH [17], due to its role in cell growth, cell proliferation, cell migration and deregulated apoptosis. The gene discussed is AKT1; the disease is pulmonary arterial hypertension.