Variables finally included in the multivariate analysis were neutropenia, platelet< 50,000/uL, prothrombin time (PT) > 13.5 s, APTT> 33.5 s, high levels of PCT (> 0.5μg/L) and prior tigecycline therapy within 1 month. The gene discussed is CALCA; the disease is Decreased total neutrophil count.