Another indication of AD is the elevated helper T-cell type-2 cytokines (interleukin (IL)-4, IL-5, IL-13, IL- 22, IL-25, and IL-33) levels, causes an increase in serum immunoglobulin E (IgE) level and also linked to the chronicity and amplification of skin inflammation in AD [13]. Here, IL33 is linked to Alzheimer disease.