We observed that a higher degree of LRIG1 expression was associated with a better overall survival and that any degree of positive LRIG1 expression was associated with a better MCC-specific survival; however, it was not an independent prognostic marker in Cox regression multivariate analyses when age, stage at diagnosis, and MCPyV LT expression were taken into account. The gene discussed is LRIG1; the disease is Merkel cell skin cancer.