In a univariate Cox regression analysis, tumor histological type (p < 0.01), differentiation degree (p < 0.001), liver metastasis (p < 0.01), venous invasion (p < 0.0001), lymph node metastasis (p < 0.05), Nevin staging (p < 0.05), curability (p < 0.0001), and stromal ANGPTL4 expression (p < 0.05) were all significant factors affecting GBC patients’ prognosis. The gene discussed is ANGPTL4; the disease is neoplasm.