Mosaic somatic missense DICER1 variants in the RNase IIIb domain are linked to GLOW syndrome, an acronym from the reported core features of global developmental delay, lung cysts, overgrowth, and Wilms’ tumour (OMIM 618272) [2]. The gene discussed is DICER1; the disease is global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome.