Recent psychiatric studies connected Morc1 to early life stress (ELS) and depression in animals and humans highlighting the potential role of Morc1 in development and mood regulation (Nieratschker et al. 2014; Schmidt et al. 2016; Mundorf et al. 2018, 2021; Thomas et al. 2020; Bölükbas et al. 2020). Here, MORC1 is linked to depressive disorder.