Furthermore, although the melanomas arising from the Tg(mitf:BRAFV600E);p53M214K/M214K zebrafish [24] can be serially transplanted into rag2−/− zebrafish, their post-transplantation growth rates were much slower, highlighting the extraordinarily high growth rate in vivo of the nf1/pten-mutant melanomas. Here, RAG2 is linked to melanoma.