MAP2K7 and neoplasm: During the 6-day treatment course, sirolimus (rapamycin) clearly suppressed the appearance of detectable tumors, and its inhibition of tumor growth persisted for 1 to 2 weeks post treatment, in marked contrast to the rapid tumor regrowth in fish treated with MEK and PI3K inhibitors (Figs. 2c, e, 3 and S10).