Pro-survival members of the BCL2 family of proteins are required for the survival of cells undergoing autophagy [33], with tumor cells typically showing greater dependence on these pro-survival effects because of their higher-than-normal expression of BH3-only initiators of apoptosis, leading to an increased propensity to undergo apoptosis through a mechanism called “apoptotic priming” [34]. This evidence concerns the gene BCL2 and neoplasm.