CTSB and infection: Further, the immune regulatory networks associated with the immune markers measured in our study showed distinct differences in the immunogenicity of LmCen−/− and LmWT infections as indicated by markers such as miR-130, PDK4, and CTSB predicted to be present only in the LmWT but not in the LmCen−/− infection and conversely ELF3 and ACKR2 genes in LmCen−/− infection only (Supplementary Fig. 4B, C).