MAT2A and Iron deficiency anemia: In addition, SAM synthases MAT1, MAT2 and MAT3 were found to be significantly increased at the protein level in the presence of iron deficiency in Arabidopsis roots11,56, while our data suggested that Fe-deficiency stimulated the interaction of MAT1/14-3-3 s, but reduced the interaction with MAT4 in Wt and klun (Tables S5 & S6).