FBN1 and Marfan syndrome: Reduced ECM in Ehlers-Danlos syndrome (which is associated with mutations impacting on fibrillar collagens and fragility of connective tissue33 and in Marfan syndrome (associated with mutations in fibrillin-1) have been linked with an increased risk of urinary tract complications including vesico-ureteric reflux, diverticula34 and rupture from overdistension35.